BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …

Many different lifestyle factors and chemicals present in the environment are a threat to the
reproductive tracts of humans. The potential for parental preconception exposure to alter …

Background The most common sex chromosomal aneuploidy in males is Klinefelter
syndrome, which is characterized by at least one supernumerary X chromosome. While …

Background Several studies have reported an association between male infertility and
aberrant sperm DNA methylation patterns, in particular in imprinted genes. In a recent …

Mental illness is a significant global health issue with a steady prevalence. High heritability
is suspected, but genome-wide association studies only identified a small number of risk …

Germ cell quality is a key prerequisite for successful fertilization and early embryo
development. The quality is determined by the fine regulation of transcriptomic and …

Epigenetic changes are important for understanding complex trait variation and inheritance
in pigs that are also a valuable biomedical model for human health research. Testis is the …

Background Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility
therapy for childhood cancer survivors. SSCT starts with cryopreserving a testicular biopsy …

Background In the past 15 years, numerous studies have described aberrant DNA
methylation of imprinted genes (eg MEST and H19) in sperm of oligozoospermic men, but …