Alphaviruses cause severe human illnesses including persistent arthritis and fatal
encephalitis. As alphavirus entry into target cells is the first step in infection, intensive …

Recent work has identified three distinct classes of viral membrane fusion proteins based on
structural criteria. In addition, there are at least four distinct mechanisms by which viral fusion …

The interferon-inducible transmembrane (IFITM) protein family represents a new class of
cellular restriction factors that block early stages of viral replication; the underlying …

The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus
mosquito, is a major factor contributing to its ongoing re-emergence in a series of large …

Hepatitis C virus (HCV), a major cause of chronic liver disease in humans, is the focus of
intense research efforts worldwide. Yet structural data on the viral envelope glycoproteins …

Chikungunya virus (CHIKV) causes a severe and often persistent arthralgic disease that is
occasionally fatal. A mosquito-borne virus, CHIKV exists in enzootic, nonhuman primate …

The structures of glycoproteins that mediate enveloped virus entry into cells have revealed
dramatic structural changes that accompany membrane fusion and provided mechanistic …

Enveloped viruses infect host cells by a membrane fusion reaction that takes place at the
cell surface or in intracellular compartments following virus uptake. Fusion is mediated by …

The emerging and re-emerging viral infections are constant threats to human health and
wellbeing. Several strategies have been explored to develop vaccines against these viral …

Flavivirus membrane fusion is mediated by a class II viral fusion protein, the major envelope
protein E, and the fusion process is extremely fast and efficient. Understanding of the …