Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
Inwardly rectifying potassium channels: their structure, function, and physiological roles
H Hibino, A Inanobe, K Furutani… - Physiological …, 2010 - journals.physiology.org
Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …
cell. They have diverse physiological functions depending on their type and their location …
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)–
induced signals. We show here that mice doubly deficient in either A20 and TNF or A20 and …
induced signals. We show here that mice doubly deficient in either A20 and TNF or A20 and …
KATP Channels in the Cardiovascular System
MN Foster, WA Coetzee - Physiological reviews, 2016 - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …
electrophysiological methods has allowed for a detailed characterization of KATP channels …
KATP channels as molecular sensors of cellular metabolism
CG Nichols - Nature, 2006 - nature.com
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …
activity provides a unique link between cellular energetics and electrical excitability. Over …
[HTML][HTML] Coronary artery spasm: new insights
A Matta, F Bouisset, T Lhermusier… - Journal of …, 2020 - hindawi.com
Coronary artery spasm (CAS) defined by a severe reversible diffuse or focal vasoconstriction
is the most common diagnosis among INOCA (ischemia with no obstructive coronary artery …
is the most common diagnosis among INOCA (ischemia with no obstructive coronary artery …
[HTML][HTML] ATP-sensitive potassium channelopathies: focus on insulin secretion
FM Ashcroft - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
ATP-sensitive potassium (KATP) channels, so named because they are inhibited by
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …
[HTML][HTML] Coronary artery spasm: review and update
MJ Hung, P Hu, MY Hung - International Journal of Medical …, 2014 - ncbi.nlm.nih.gov
Coronary artery spasm (CAS), an intense vasoconstriction of coronary arteries that causes
total or subtotal vessel occlusion, plays an important role in myocardial ischemic syndromes …
total or subtotal vessel occlusion, plays an important role in myocardial ischemic syndromes …
[HTML][HTML] Physiological and pathophysiological roles of ATP-sensitive K+ channels
S Seino, T Miki - Progress in biophysics and molecular biology, 2003 - Elsevier
ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …