Cell polarity relies on the asymmetric organization of cellular components and structures.
Actin and microtubules are well suited to provide the structural basis for cell polarization …

Polarization, a primary step in the response of an individual eukaryotic cell to a spatial
stimulus, has attracted numerous theoretical treatments complementing experimental …

Motile eukaryotic cells polarize in response to external signals. Numerous mechanisms
have been suggested to account for this symmetry breaking and for the ensuing robust …

Complex biochemical networks can be understood by identifying their principal regulatory
motifs and mode of action. We model the early phase of budding yeast cellular polarization …

Chemotaxis in eukaryotic cells involves the coordination of several related but separable
processes: motility, polarization, and gradient sensing. Mathematical models that have been …

Eukariotic cell motility is a complex phenomenon, in which the cytoskeleton and its major
constituent, actin, play an essential role. Actin forms polymers of long, stiff filaments that are …

Many types of cells are able to accurately sense shallow gradients of chemicals across their
diameters, allowing the cells to move toward or away from chemical sources. This …

How cells form global, self-organized structures using genetically encoded molecular rules
remains elusive. Here, we take a synthetic biology approach to investigate the design …

Wiring up the nervous system depends on the precise guidance of axonal growth cones to
their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth …

To regulate shape changes, motility and chemotaxis in eukaryotic cells, signal transduction
pathways channel extracellular stimuli to the reorganization of the actin cytoskeleton. The …