Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

Thirty years ago, De Bold et al. reported that atrial extracts contain some biologically active
peptides, which promote a rapid and massive diuresis and natriuresis when injected in rats …

The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing
factors that regulate local blood flow, systemic blood pressure, and the reactivity of …

The endothelium maintains vascular homeostasis through the release of active vasodilators.
Although nitric oxide (NO) is recognized as the primary factor at level of conduit arteries …

Natriuretic peptides (NPs), including atrial, brain and C‐type natriuretic peptides (ANP, BNP
and CNP), bind two classes of cell surface receptors: the guanylyl cyclase‐linked A and B …

Obesity has become a serious global health issue affecting both adults and children. Recent
devolopments in world demographics and declining health status of the world's population …

Arterial hyperpolarization to acetylcholine (ACh) reflects coactivation of KCa3. 1 (IKCa)
channels and KCa2. 3 (SKCa) channels in the endothelium that transfers through …