Disease overview Chronic lymphocytic leukemia (CLL) is one of the most frequent types of
leukemia. It typically occurs in elderly patients and has a highly variable clinical course …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers.
However, we lack experimental models for validating their tumorigenic impact. Here, we …

Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …

Metastasis is a multistep process by which cancer cells break away from their original
location and spread to distant organs, and is responsible for the vast majority of cancer …

Discovering rare cancer driver genes is difficult because their mutational frequency is too
low for statistical detection by computational methods. EPIMUTESTR is an integrative …

Simple Summary A concept is presented for a new therapeutic approach, still in its early
stages, which focuses on the phenotypic mimicry (“mimesis”) of proteins encoded by highly …

It is well known that certain non B-DNA structures, including G-quadruplexes, are key
elements that can regulate gene expression. Here, we explore the theory that DNA …

DNA methylation is one of the epigenetic modifications of the genome, the essence of which
is the attachment of a methyl group to nitrogenous bases. In the eukaryote genome, cytosine …