Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

[HTML][HTML] The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Inside (sight) of tiny communicator: exosome biogenesis, secretion, and uptake

AS Jadli, N Ballasy, P Edalat, VB Patel - Molecular and cellular …, 2020 - Springer
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …

Biogenesis, membrane trafficking, functions, and next generation nanotherapeutics medicine of extracellular vesicles

S Gurunathan, MH Kang, M Qasim… - International Journal of …, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and
multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two …

Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor …

SS Yang, S Ma, H Dou, F Liu, SY Zhang, C Jiang… - Experimental cell …, 2020 - Elsevier
Objective To explore the effects of breast cancer (BC)-derived exosomes on invasion and
migration of BC cells. Methods Exosomes (Exo-MA, Exo-M7, Exo-M1) were extracted from …

[HTML][HTML] A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy

J Li, Y Zhang, PY Dong, GM Yang… - Biomedicine & …, 2023 - Elsevier
All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …

[HTML][HTML] High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism

LA Ambattu, S Ramesan, C Dekiwadia… - Communications …, 2020 - nature.com
Exosomes are promising disease diagnostic markers and drug delivery vehicles, although
their use in practice is limited by insufficient homogeneous quantities that can be produced …

[HTML][HTML] Leptin: A heavyweight player in obesity-related cancers

A Caruso, L Gelsomino, S Panza, FM Accattatis… - Biomolecules, 2023 - mdpi.com
Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has
reached pandemic proportions and is recognized as an important health concern since it is …

Linkage between obesity leptin and breast cancer

MF Atoum, F Alzoughool… - Breast Cancer: Basic …, 2020 - journals.sagepub.com
Many cancers might be influenced by obesity, including breast cancer, the leading cause of
cancer death among women. Obesity is a complex state associated with multiple …

[HTML][HTML] The biology of exosomes in breast cancer progression: dissemination, immune evasion and metastatic colonization

C Giordano, G La Camera, L Gelsomino, I Barone… - Cancers, 2020 - mdpi.com
In recent decades, the study of exosome biology has gained growing interest, representing
an active area of cancer research with many potential clinical applications. Exosomes are …