The objective of this review is to provide an update on the fluorine-containing drugs
approved by US Food and Drug Administration in the span of past five years (2018–2022) …

Neurodegenerative diseases such as Parkinson's disease (PD) are manifested by inclusion
bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these …

The term “click chemistry” describes a class of organic transformations that were developed
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …

It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for
the treatment of Parkinson's disease. However, brain penetration of antibodies is hampered …

Biologic drugs are large molecule pharmaceuticals that do not cross the blood–brain barrier
(BBB), which is formed by the brain capillary endothelium. Biologics can be re-engineered …

This article presents an overview of imaging agents for PET that have been applied for
research and diagnostic purposes in patients affected by dementia. Classified by the target …

Background Hijacking the transferrin receptor (TfR) is an effective strategy to transport
amyloid-beta (Aβ) immuno-positron emission tomography (immunoPET) ligands across the …

Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA)
reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive …

Background Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor
overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography …