Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

Lung cancer remains the leading cause of cancer mortality in men and women in the US
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …

Purpose To provide guidance to clinicians regarding therapy for patients with brain
metastases from solid tumors. Methods ASCO convened an Expert Panel and conducted a …

Background Whole brain radiotherapy (WBRT) and dexamethasone are widely used to treat
brain metastases from non-small cell lung cancer (NSCLC), although there have been no …

Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …

Since the discovery of its facile synthesis in 2001, meso-aryl-substituted expanded
porphyrins have been developed as a new class of azaannulenes in light of their facile …

Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

Background and purpose Brain metastasis impacts greatly on patients' quality of life and
survival. The phase I NANO-RAD trial assessed the safety and maximum tolerated dose of …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …