Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery

GA Quinn, AM Banat… - Journal of medical …, 2020 - microbiologyresearch.org
Given the increased reporting of multi-resistant bacteria and the shortage of newly approved
medicines, researchers have been looking towards extreme and unusual environments as a …

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

PJ Rutledge, GL Challis - Nature reviews microbiology, 2015 - nature.com
Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

The ecological role of volatile and soluble secondary metabolites produced by soil bacteria

O Tyc, C Song, JS Dickschat, M Vos, P Garbeva - Trends in microbiology, 2017 - cell.com
The rich diversity of secondary metabolites produced by soil bacteria has been appreciated
for over a century, and advances in chemical analysis and genome sequencing continue to …

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

Strategies to diversify natural products for drug discovery

G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Molecular regulation of antibiotic biosynthesis in Streptomyces

G Liu, KF Chater, G Chandra, G Niu… - … and molecular biology …, 2013 - Am Soc Microbiol
Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

[图书][B] Geomicrobiology

HL Ehrlich, DK Newman - 2008 - taylorfrancis.com
Uncovers the Key Role Microbes Play in the Transformation of Oxidizable and Reducible
MineralsMany areas of geomicrobial processes are receiving serious attention from …

[HTML][HTML] Activation of microbial secondary metabolic pathways: Avenues and challenges

B Baral, A Akhgari, M Metsä-Ketelä - Synthetic and Systems Biotechnology, 2018 - Elsevier
Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

[HTML][HTML] Elicitation of secondary metabolism in actinomycetes

UR Abdelmohsen, T Grkovic, S Balasubramanian… - Biotechnology …, 2015 - Elsevier
Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …