[HTML][HTML] Immunopathogenesis of rheumatoid arthritis

GS Firestein, IB McInnes - Immunity, 2017 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift

KD Deane, VM Holers - Arthritis & Rheumatology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

J González‐Febles, M Sanz - Periodontology 2000, 2021 - Wiley Online Library
Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined
respectively by the destruction of the articular cartilage and tooth‐supporting periodontal …

The pathogenesis of rheumatoid arthritis

IB McInnes, G Schett - New England Journal of Medicine, 2011 - Mass Medical Soc
The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

[HTML][HTML] The therapeutic landscape of rheumatoid arthritis: current state and future directions

S Shams, JM Martinez, JRD Dawson, J Flores… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

[HTML][HTML] Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis

J Sokolove, R Bromberg, KD Deane, LJ Lahey… - PloS one, 2012 - journals.plos.org
Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the
world population and is a significant cause of worldwide disability. Though prior studies …

[HTML][HTML] Systemic inflammation in preclinical ulcerative colitis

D Bergemalm, E Andersson, J Hultdin, C Eriksson… - Gastroenterology, 2021 - Elsevier
Background & Aims Preclinical ulcerative colitis is poorly defined. We aimed to characterize
the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of …

[HTML][HTML] Preclinical autoimmune disease: a comparison of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and type 1 diabetes

G Frazzei, RF van Vollenhoven, BA de Jong… - Frontiers in …, 2022 - frontiersin.org
The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …

Rheumatoid factors: clinical applications

F Ingegnoli, R Castelli, R Gualtierotti - Disease markers, 2013 - Wiley Online Library
Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First
detected in patients with rheumatoid arthritis 70 years ago, they can also be found in …