The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
Structural mechanisms of the mTOR pathway
KY Linde-Garelli, KB Rogala - Current Opinion in Structural Biology, 2023 - Elsevier
The mTOR signaling pathway is essential for regulating cell growth and mammalian
metabolism. The mTOR kinase forms two complexes, mTORC1 and mTORC2, which …
metabolism. The mTOR kinase forms two complexes, mTORC1 and mTORC2, which …
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition
G Figlia, S Müller, AM Hagenston, S Kleber… - Nature Cell …, 2022 - nature.com
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to
appropriately regulate cellular anabolism and catabolism. During nutrient restriction …
appropriately regulate cellular anabolism and catabolism. During nutrient restriction …
mTORC1 activity licenses its own release from the lysosomal surface
A Acharya, C Demetriades - Molecular Cell, 2024 - cell.com
Nutrient signaling converges on mTORC1, which, in turn, orchestrates a physiological
cellular response. A key determinant of mTORC1 activity is its shuttling between the …
cellular response. A key determinant of mTORC1 activity is its shuttling between the …
Cryo-EM structure of the SEA complex
The SEA complex (SEAC) is a growth regulator that acts as a GTPase-activating protein
(GAP) towards Gtr1, a Rag GTPase that relays nutrient status to the Target of Rapamycin …
(GAP) towards Gtr1, a Rag GTPase that relays nutrient status to the Target of Rapamycin …
Growth or death? Control of cell destiny by mTOR and autophagy pathways
One of the central regulators of cell growth, proliferation, and metabolism is the mammalian
target of rapamycin, mTOR, which exists in two structurally and functionally different …
target of rapamycin, mTOR, which exists in two structurally and functionally different …
mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes
S Zwakenberg, D Westland, RM van Es, H Rehmann… - Molecular Cell, 2024 - cell.com
To stimulate cell growth, the protein kinase complex mTORC1 requires intracellular amino
acids for activation. Amino-acid sufficiency is relayed to mTORC1 by Rag GTPases on …
acids for activation. Amino-acid sufficiency is relayed to mTORC1 by Rag GTPases on …
[HTML][HTML] PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
C Jiang, J Liu, S He, W Xu, R Huang, W Pan, X Li… - Cell Metabolism, 2023 - cell.com
Methionine is an essential branch of diverse nutrient inputs that dictate mTORC1 activation.
In the absence of methionine, SAMTOR binds to GATOR1 and inhibits mTORC1 signaling …
In the absence of methionine, SAMTOR binds to GATOR1 and inhibits mTORC1 signaling …
Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation
The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and
catabolism in response to nutrients through phosphorylation of key substrates. The tumor …
catabolism in response to nutrients through phosphorylation of key substrates. The tumor …
[HTML][HTML] Amino acid sensing and lysosomal signaling complexes
Amino acid pools in the cell are monitored by dedicated sensors, whose structures are now
coming into view. The lysosomal Rag GTPases are central to this pathway, and the …
coming into view. The lysosomal Rag GTPases are central to this pathway, and the …