Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …

Sex hormone-dependent cancers currently contribute to the high number of cancer-related
deaths worldwide. The study and elucidation of the molecular mechanisms underlying the …

The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2
protein between the high-activity and low-activity states that allow ATP and lactate …

Background Pancreatic adenocarcinoma (PAAD) is a severe malignant with a 5-year
survival rate of approximately 9%. Oleanolic acid is a well-known natural triterpenoid which …

Glioma ranks first among the aggressive brain tumors all over the world. LncRNA
LINC00689 has been confirmed to play key roles in the progression of cancers, and …

Introduction of α-cyano α, β-unsaturated carbonyl moiety into natural cyclic compounds
markedly improves their bioactivities, including inhibitory potential against tumor growth and …

To investigate the potential antitumor activity of synthetic triterpenoid, methyl‐2‐cyano‐3, 12‐
dioxooleana‐1, 9 (11)‐dien‐28‐oate (CDDO‐Me) in pancreatic ductal adenocarcinoma …

Bartogenic acid (BA), a natural pentacyclic triterpenoid, proved to have chemomodulatory,
anticancer, antidiabetic, anti-arthritic, and anti-inflammatory activity. Based on structure …