From cocoa to chocolate: Effect of processing on flavanols and methylxanthines and their mechanisms of action
L Goya, JE Kongor, S de Pascual-Teresa - International Journal of …, 2022 - mdpi.com
Despite the health benefits associated with the ingestion of the bioactive compounds in
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …
Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin
FC Cadoná, RF Dantas, GH de Mello… - Critical Reviews in …, 2022 - Taylor & Francis
Natural products have been studied to reveal new therapies against human dysfunctions
since they present several medicinal properties. Caffeine, theobromine and (+)-catechin are …
since they present several medicinal properties. Caffeine, theobromine and (+)-catechin are …
New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic
theobromine-derived compound was designed to interact with the catalytic pocket of EGFR …
theobromine-derived compound was designed to interact with the catalytic pocket of EGFR …
Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and …
A group of theobromine derivatives was designed based on the key pharmacophoric
characteristics of VEGFR-2 inhibitors. HepG2 and MCF-7 cancer cell lines were used to test …
characteristics of VEGFR-2 inhibitors. HepG2 and MCF-7 cancer cell lines were used to test …
Anti-breast cancer potential of a new xanthine derivative: in silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies
Background The overexpression of VEGFR-2 receptors in breast cancer provides a valuable
approach to anticancer strategies. Targeting VEGFR-2, a new semisynthetic compound (T-1 …
approach to anticancer strategies. Targeting VEGFR-2, a new semisynthetic compound (T-1 …
New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations
HA Mahdy, H Elkady, MS Taghour… - Future Medicinal …, 2023 - Taylor & Francis
Background: VEGFR-2 is one of the most effective targets in cancer treatment. Aim: The
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies
This study aimed to design anticancer theobromine derivatives inhibiting VEGFR-2. The new
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …
[HTML][HTML] Paullinia cupana: a multipurpose plant–a review
LLM Marques, EDF Ferreira, MN de Paula… - Revista Brasileira de …, 2019 - Elsevier
Seeds of guarana (Paullinia cupana Kunth, Sapindaceae) feature diverse pharmacological
functions, for example, antimicrobial, antioxidant, anticarcinogenic, stimulating, and …
functions, for example, antimicrobial, antioxidant, anticarcinogenic, stimulating, and …
Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning
EJ Mucaki, JZL Zhao, DJ Lizotte… - Signal transduction and …, 2019 - nature.com
The selection of effective genes that accurately predict chemotherapy responses might
improve cancer outcomes. We compare optimized gene signatures for cisplatin, carboplatin …
improve cancer outcomes. We compare optimized gene signatures for cisplatin, carboplatin …
[HTML][HTML] Exploiting systems biology to investigate the gene modules and drugs in ovarian cancer: A hypothesis based on the weighted gene co-expression network …
Background Ovarian cancer (OC) is one of the worrisome gynecological cancers worldwide.
Given its considerable mortality rate, it is necessary to investigate its oncogenesis. Methods …
Given its considerable mortality rate, it is necessary to investigate its oncogenesis. Methods …