Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …

In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm, in a process called spermiogenesis. This process is distinct from …

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

The past decade has seen a tremendous increase in interest and progress in the field of
sperm epigenetics. Studies have shown that chromatin regulation during male germline …

Histone H1 is the most variable histone and its role at the epigenetic level is less
characterized than that of core histones. In vertebrates, H1 is a multigene family, which can …

Male germ cells undergo an extreme but fascinating process of chromatin remodeling that
begins in the testis during the last phase of spermatogenesis and continues through …

Background During the process of spermatogenesis, male germ cells undergo dramatic
chromatin reorganization, whereby most histones are replaced by protamines, as part of the …

Although advances in single-cell technologies have enabled the characterization of multiple
omics profiles in individual cells, extracting functional and mechanistic insights from such …

Background A pseudogene is a gene copy that has lost its original coding ability.
Pseudogenes participate in numerous biological processes including oncogenesis …

Background Linker histones establish and maintain higher-order chromatin structure. Eleven
linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific …