Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm
S Seal, G Dharmarajan, I Khan - Elife, 2021 - elifesciences.org
Researchers worldwide are repeatedly warning us against future zoonotic diseases
resulting from humankind's insurgence into natural ecosystems. The same zoonotic …
resulting from humankind's insurgence into natural ecosystems. The same zoonotic …
[HTML][HTML] Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition
The severity of SARS-CoV-2 infection is highly variable and yet the molecular basis for this
effect remains elusive. One potential contribution are differences in the glycosylation of …
effect remains elusive. One potential contribution are differences in the glycosylation of …
Evolutionary arms race between virus and host drives genetic diversity in bat severe acute respiratory syndrome-related coronavirus spike genes
ABSTRACT The Chinese horseshoe bat (Rhinolophus sinicus), reservoir host of severe
acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs …
acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs …
Backyard zoonoses: The roles of companion animals and peri-domestic wildlife
A Gamble, XA Olarte-Castillo… - Science Translational …, 2023 - science.org
The spillover of human infectious diseases from animal reservoirs is now well appreciated.
However, societal and climate-related changes are affecting the dynamics of such …
However, societal and climate-related changes are affecting the dynamics of such …
[HTML][HTML] Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans
CJ Warren, S Yu, DK Peters, A Barbachano-Guerrero… - Cell, 2022 - cell.com
Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic
fevers when they cross into primate hosts of new species. We find that CD163 acts as an …
fevers when they cross into primate hosts of new species. We find that CD163 acts as an …
[HTML][HTML] Infection pressure in apes has driven selection for CD4 alleles that resist lentivirus (HIV/SIV) infection
CJ Warren, A Barbachano-Guerrero, VL Bauer… - eLife, 2024 - elifesciences.org
Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
Endosidin20 targets the cellulose synthase catalytic domain to inhibit cellulose biosynthesis
Plant cellulose is synthesized by rosette-structured cellulose synthase (CESA) complexes
(CSCs). Each CSC is composed of multiple subunits of CESAs representing three different …
(CSCs). Each CSC is composed of multiple subunits of CESAs representing three different …
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses
RM Russell, F Bibollet-Ruche, W Liu… - Proceedings of the …, 2021 - National Acad Sciences
Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the
viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells …
viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells …
Selective use of primate CD4 receptors by HIV-1
CJ Warren, NR Meyerson, O Dirasantha… - PLoS …, 2019 - journals.plos.org
Individuals chronically infected with HIV-1 harbor complex viral populations within their
bloodstreams. Recently, it has come to light that when these people infect others, the new …
bloodstreams. Recently, it has come to light that when these people infect others, the new …
Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes
Abstract The Chinese horseshoe bat (Rhinolophus sinicus), reservoir host of severe acute
respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs …
respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs …