Microbiota metabolites in health and disease

JL McCarville, GY Chen, VD Cuevas… - Annual review of …, 2020 - annualreviews.org
Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

Nutritional iron turned inside out: intestinal stress from a gut microbial perspective

GAM Kortman, M Raffatellu… - FEMS microbiology …, 2014 - academic.oup.com
Iron is abundantly present on earth, essential for most microorganisms and crucial for
human health. Human iron deficiency that is nevertheless highly prevalent in developing …

The role of iron and siderophores in infection, and the development of siderophore antibiotics

MGP Page - Clinical Infectious Diseases, 2019 - academic.oup.com
Iron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …

Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence

JR Sheldon, EP Skaar - PLoS pathogens, 2020 - journals.plos.org
Acinetobacter baumannii is an emerging pathogen that poses a global health threat due to a
lack of therapeutic options for treating drug-resistant strains. In addition to acquiring …

[HTML][HTML] The iron tug-of-war between bacterial siderophores and innate immunity

R Golonka, BS Yeoh, M Vijay-Kumar - Journal of innate immunity, 2019 - karger.com
Iron is necessary for the survival of almost all aerobic organisms. In the mammalian host,
iron is a required cofactor for the assembly of functional iron-sulfur (Fe-S) cluster proteins …

Coordination chemistry of microbial iron transport

KN Raymond, BE Allred, AK Sia - Accounts of chemical research, 2015 - ACS Publications
Conspectus This Account focuses on the coordination chemistry of the microbial iron
chelators called siderophores. The initial research (early 1970s) focused on simple analogs …

Vibrio iron transport: evolutionary adaptation to life in multiple environments

SM Payne, AR Mey, EE Wyckoff - Microbiology and Molecular …, 2016 - Am Soc Microbiol
Iron is an essential element for Vibrio spp., but the acquisition of iron is complicated by its
tendency to form insoluble ferric complexes in nature and its association with high-affinity …

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Q Long, W Zhou, H Zhou, Y Tang, W Chen… - Natural Product …, 2024 - pubs.rsc.org
Covering: 2005 to August, 2023 Polyamine-containing natural products (NPs) have been
isolated from a wide range of terrestrial and marine organisms and most of them exhibit …

[HTML][HTML] Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections

D Nasioudis, SS Witkin - Medical Microbiology and Immunology, 2015 - Springer
Neutrophil gelatinase-associated lipocalin (NGAL), an essential component of the
antimicrobial innate immune system, is present in neutrophils and multiple other tissues. It …

New antibiotics from Nature's chemical inventory

TA Wencewicz - Bioorganic & medicinal chemistry, 2016 - Elsevier
The doom and gloom of antibiotic resistance dominates public perception of this drug class.
Many believe the world has entered the post-antibiotic era. Classic and modern approaches …