Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Obesity is a worldwide health problem, and as its prevalence increases, so does the burden
of obesity-associated co-morbidities like type 2 diabetes or cardiovascular diseases (CVDs) …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …

While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …

Objective Obesity-induced insulin resistance is closely associated with chronic subclinical
inflammation in white adipose tissue. However, the mechanistic involvement of adipocyte …

Adipose tissue (AT) is one of the largest endocrine organs contributing to metabolic
homeostasis. The functional pleiotropism of AT depends on its ability to secrete a large …

Obesity is characterized by pathological adipose tissue (AT) expansion. While healthy AT
expansion enhances systemic insulin sensitivity, unhealthy AT expansion through increased …

The vascular endothelium serves as a dynamic barrier that separates blood from interstitia.
Endothelial cells (ECs) respond rapidly to changes in the circulation and actively regulate …