[HTML][HTML] Pharmaceutical formulations with P-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …
Multidrug resistance in cancer: role of ATP–dependent transporters
MM Gottesman, T Fojo, SE Bates - Nature reviews cancer, 2002 - nature.com
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …
Mechanisms of cancer drug resistance
MM Gottesman - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet
there is no cancer treatment that is 100% effective against disseminated cancer. Resistance …
there is no cancer treatment that is 100% effective against disseminated cancer. Resistance …
Mammalian ABC transporters in health and disease
P Borst, RO Elferink - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …
membranes and are able to transport a variety of compounds through membranes against …
P-glycoprotein: from genomics to mechanism
Resistance to chemically different natural product anti-cancer drugs (multidrug resistance, or
MDR) results from decreased drug accumulation, resulting from expression of one or more …
MDR) results from decreased drug accumulation, resulting from expression of one or more …
Structure of a bacterial multidrug ABC transporter
RJP Dawson, KP Locher - Nature, 2006 - nature.com
Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across
cell membranes. This is clinically relevant, as tumour cells may become resistant to agents …
cell membranes. This is clinically relevant, as tumour cells may become resistant to agents …
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
SF Zhou - Xenobiotica, 2008 - Taylor & Francis
1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …
The ATP switch model for ABC transporters
CF Higgins, KJ Linton - Nature structural & molecular biology, 2004 - nature.com
ABC transporters mediate active translocation of a diverse range of molecules across all cell
membranes. They comprise two nucleotide-binding domains (NBDs) and two …
membranes. They comprise two nucleotide-binding domains (NBDs) and two …
Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …