Rates of individuals struggling with psychostimulant use disorder (PSUD), defined as
chronic use of psychostimulants despite negative consequences, are growing rapidly over …

Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that
enables genes to choose between multiple genomic loci for initiating transcription. This …

The severity of Alzheimer9s disease (AD) progression involves a complex interplay of
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …

Background The ability of neurons to respond to external stimuli involves adaptations of
gene expression. Induction of the transcription factor ΔFOSB in the nucleus accumbens, a …

Drug addiction is a complex disease affected by numerous genetic and environmental
factors. Brain regions in reward pathway, neuronal adaptations, genetic and epigenetic …

Increasing evidence suggests that alternative splicing plays a critical role in pain, but its
underlying mechanism remains elusive. Herein, we employed complete Freund's adjuvant …

The primary sensory neurons of the dorsal root ganglia (DRG) are subject to transcriptional
alterations following peripheral nerve injury. These alterations are believed to play a pivotal …

The dorsal striatum integrates prior and current information to guide appropriate decision-
making. Chronic stress and stimulant exposure interferes with decision-making, and can …

DNA methylation is an essential epigenetic mark, strongly associated with gene expression
regulation. Aberrant DNA methylation patterns underlie various diseases and efforts to …

During the initial stages of drug use, cocaine-induced neuroadaptations within the ventral
tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement …