Molecular probes, chemosensors, and nanosensors for optical detection of biorelevant molecules and ions in aqueous media and biofluids

J Krämer, R Kang, LM Grimm, L De Cola… - Chemical …, 2022 - ACS Publications
Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …

Further dimensions for sensing in biofluids: distinguishing bioorganic analytes by the salt-induced adaptation of a cucurbit [7] uril-based chemosensor

C Hu, T Jochmann, P Chakraborty… - Journal of the …, 2022 - ACS Publications
Insufficient binding selectivity of chemosensors often renders biorelevant metabolites
indistinguishable by the widely used indicator displacement assay. Array-based …

Chemiluminescent Cucurbit[n]uril-Based Chemosensor for the Detection of Drugs in Biofluids

NM Kumar, P Picchetti, C Hu, LM Grimm… - ACS …, 2022 - ACS Publications
Chemiluminescence-based detection methods offer a superior signal-to-noise ratio and are
commonly adopted for biosensors. This work presents the design and implementation of a …

Electrochemical Detection of Drugs via a Supramolecular Cucurbit [7] uril-Based Indicator Displacement Assay

NM Kumar, P Gruhs, A Casini, F Biedermann… - ACS …, 2023 - ACS Publications
Electrochemical detection methods are attractive for developing miniaturized, disposable,
and portable sensors for molecular diagnostics. In this article, we present a cucurbit [7] uril …

Cucurbit[n]uril-Immobilized Sensor Arrays for Indicator-Displacement Assays of Small Bioactive Metabolites

C Zhong, C Hu, R Kumar, V Trouillet… - ACS Applied Nano …, 2021 - ACS Publications
The patterned immobilization of chemosensors into nano/microarrays has often boosted
utilization in diagnostics and environmental sensing applications. While this is a standard …

[HTML][HTML] Analyte sensing with unselectively binding synthetic receptors: virtues of time-resolved supramolecular assays

A Prabodh, S Sinn, F Biedermann - Chemical Communications, 2022 - pubs.rsc.org
The cross-reactivity to many analytes is one major limitation of most synthetic receptors
(SRs) known so far. Herein, we show that through time-resolved competitive binding assays …

Cucurbituril-mediated AIE: An unconventional indicator displacement assay for ketamine detection

K Yan, L Wang, H Zhou, Z Hua, P Xu, H Xu, Y Wang… - Dyes and …, 2022 - Elsevier
Typical AIE luminogens with extensive π-electron conjugation are limited in use on account
of their complex synthesis, high cost and environmental concerns. To this end, we report …

[HTML][HTML] Elucidating dissociation activation energies in host–guest assemblies featuring fast exchange dynamics

R Shusterman-Krush, L Grimm, L Avram… - Chemical …, 2021 - pubs.rsc.org
The ability to mediate the kinetic properties and dissociation activation energies (Ea) of
bound guests by controlling the characteristics of “supramolecular lids” in host–guest …

From Molecules to Materials: Collaborative Research at the Chemistry—Materials Science Interface and Lessons Learned in Cyclophane Chemistry

Z Hassan, E Zysman‐Colman… - Advanced Functional …, 2024 - Wiley Online Library
In the spirit of pursuing collaborative research at the interface of chemistry and materials
science for engineering cyclophane‐based functional systems, the journey from molecules …

Polymersome-Encapsulated Chemosensors: New Design Strategies toward Biofluid-Applicable Cucurbit [7] uril Indicator Displacement Assays

P Picchetti, AK Pearce, SJ Parkinson, LM Grimm… - …, 2024 - ACS Publications
The development of supramolecular cucurbit [7] uril-based chemosensors for the detection
of bioanalytes in biofluids such as untreated human serum and inside cells is a challenging …