Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very
heterogeneous biological and clinical behavior. The last decade has been remarkably …

IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …

Pattern recognition receptors (PRRs) expressed on immune cells are crucial for the early
detection of invading pathogens, in initiating early innate immune response and in …

Purpose: MYD88 mutations, notably the recurrent gain-of-function L265P variant, are a
distinguishing feature of activated B-cell like (ABC) diffuse large B-cell lymphoma (DLBCL) …

Plasmacytic differentiation may occur in almost all small B cell lymphomas (SBLs), although
it varies from being uniformly present (as in lymphoplasmacytic lymphoma (LPL)) to very …

The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated
lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western
countries and is characterized by the clonal expansion of mature CD5+ B cells. There have …

Genetic diagnostics of hematological malignancies has evolved dramatically over the years,
from chromosomal banding analysis to next-generation sequencing, with a corresponding …

Recurrent mutations in MYD 88 have been identified in> 90% of lymphoplasmacytic
lymphoma (LPL). Recently, WHIM (warts, hypogammaglobulinaemia, infections …