Disruption of Ca 2+ homeostasis can lead to severe damage of the pancreas, resulting in
premature activation of digestive enzymes, vacuolisation and necrotic cell death, features …

Endoplasmic reticulum (ER)–plasma membrane (PM) junctions are contact sites between
the ER and the PM; the distance between the two organelles in the junctions is below 40 nm …

Abstract Aims: Pulmonary infections with Pseudomonas aeruginosa are a serious clinical
problem and are often lethal. Because many strains of P. aeruginosa are resistant to …

Background In severe acute pancreatitis (AP) the CNS is affected manifesting in
neurological symptoms. Earlier research from our laboratory showed blood–brain barrier …

The present study aimed to determine the chemical composition, antioxidant effects and
antitumor properties of a methanol extract of Anchusa azurea Mill.(Boraginaceae) aerial …

Acute pancreatitis (AP) is a sudden pancreatic inflammation accompanied by an excessive
reactive oxygen species production that provokes inflammation. The present study …

Pancreatic acinar cells require high rates of amino acid uptake for digestive enzyme
synthesis, but excessive concentrations can trigger acute pancreatitis (AP) by mechanisms …

Key points Giant trypsin‐containing endocytic vacuoles are formed in pancreatic acinar cells
stimulated with inducers of acute pancreatitis. F‐actin envelops endocytic vacuoles and …

Significance: Metabolic end products and intermediates can exert signaling functions as
chemical sources for histone posttranslational modifications, which remodel chromatin and …

Although oxidative stress has been strongly implicated in the development of acute
pancreatitis (AP), antioxidant therapy in patients has so far been discouraging. The aim of …