A subject of extensive study in evolutionary theory has been the issue of how neutral,
redundant copies can be maintained in the genome for long periods of time. Concurrently …

While the vast majority of cellular DNA in eukaryotes is contained in long linear strands in
chromosomes, we have long recognized some exceptions like mitochondrial DNA, plasmids …

Retrotransposons are highly enriched in the animal genome,–. The activation of
retrotransposons can rewrite host DNA information and fundamentally impact host biology …

The human genome is generally organized into stable chromosomes, and only tumor cells
are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements …

Examples of extrachromosomal circular DNAs (eccDNAs) are found in many organisms, but
their impact on genetic variation at the genome scale has not been investigated. We …

Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Over the past few years, genome sequences have become available from an increasing
range of yeast species, which has led to notable advances in our understanding of …

Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …

Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid
and extensive gene copy number variation and is implicated in the pathology of cancer and …