Inflammasomes: mechanisms of action and involvement in human diseases

D Bulté, C Rigamonti, A Romano, A Mortellaro - Cells, 2023 - mdpi.com
Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

Genetics of oocyte maturation defects and early embryo development arrest

OA Solovova, VB Chernykh - Genes, 2022 - mdpi.com
Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

Comprehensive transcriptomic analysis of long non-coding RNAs in bovine ovarian follicles and early embryos

P Wang, ÉR Paquet, C Robert - Plos one, 2023 - journals.plos.org
Long non-coding RNAs (lncRNAs) have been the subject of numerous studies over the past
decade. First thought to come from aberrant transcriptional events, lncRNAs are now …

Role of NLRP7 in normal and malignant trophoblast cells

R Abi Nahed, M Elkhoury Mikhael, D Reynaud… - Biomedicines, 2022 - mdpi.com
Gestational choriocarcinoma (CC) is an aggressive cancer that develops upon the
occurrence of abnormal pregnancies such as Hydatidiform moles (HMs) or upon non-molar …

NLRP inflammasomes in health and disease

Z Xu, AJ Kombe Kombe, S Deng, H Zhang, S Wu… - Molecular …, 2024 - Springer
NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition
receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns …

NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts

A Alici-Garipcan, B Özçimen, I Süder, V Ülker… - Cell Death & …, 2020 - nature.com
Complete hydatidiform mole (HM) is a gestational trophoblastic disease resulting in
hyperproliferation of trophoblast cells and absence of embryo development. Mutations in the …

Early pregnancy modulates expression of the nod-like receptor family in lymph nodes of ewes

Z Zhao, Y Li, J Cao, H Fang, L Zhang, L Yang - Animals, 2022 - mdpi.com
Simple Summary NOD receptors mediate adaptive immune responses and immune
tolerance. In this study, the results demonstrated that early pregnancy increased expression …

Cell‐specific network analysis of human folliculogenesis reveals network rewiring in antral stage oocytes

S Wang, Y Gong, Z Wang, J Greenbaum… - Journal of Cellular …, 2021 - Wiley Online Library
Although previous studies have explored the gene expression profiles of human oocytes
and granulosa cells by single‐cell RNA sequencing (scRNA‐seq), the dynamic regulatory …

Genetic variants underlying developmental arrests in human preimplantation embryos

S Ozturk - Molecular Human Reproduction, 2023 - academic.oup.com
Developmental arrest in preimplantation embryos is one of the major causes of assisted
reproduction failure. It is briefly defined as a delay or a failure of embryonic development in …

Mapping the anatomical and transcriptional landscape of early human fetal ovary development

SM McGlacken-Byrne, I Del Valle, T Xenakis… - bioRxiv, 2023 - biorxiv.org
The complex genetic mechanisms underlying human ovary development can give rise to
clinical phenotypes if disrupted, such as Primary Ovarian Insufficiency and Differences of …