Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC)
growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

Proteolysis-targeting chimeras (PROTACs) are a promising new class of drugs that
selectively degrade cellular proteins of interest. PROTACs that target oncogene products are …

Nanomedicine of synergistic drug combinations has shown increasing significance in
cancer therapy due to its promise in providing superior therapeutic benefits to the current …

Breast cancer is the second leading cause of cancer death in women, affecting 1.7 million
patients every year worldwide. As a result of its heterogeneous nature, the genetic profile …

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The
protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of …

The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Cancer cell resistance to chemotherapy is still a heavy burden that impairs treatment of
cancer patients. Both intrinsic and acquired resistance results from the numerous genetic …

Development of multidrug resistance (MDR) still remains a major obstacle to the long-term
success of cancer therapy. P-glycoprotein (P-gp) is a well-identified membrane transporter …