Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

Many enzymes use one or more cofactors, such as biotin, heme, or flavin. These cofactors
may be bound to the enzyme in a noncovalent or covalent manner. Although most …

Resistance against currently used antitubercular therapeutics increasingly undermines
efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) …

The benzothiazinone BTZ043 is a tuberculosis drug candidate with nanomolar whole-cell
activity. BTZ043 targets the DprE1 catalytic component of the essential enzyme …

Benzothiazinones (BTZs) form a new class of potent antimycobacterial agents. Although the
target of BTZs has been identified as decaprenylphosphoryl-β-d-ribose 2′-epimerase …

Dioxygen (O2) and other gas molecules have a fundamental role in a variety of enzymatic
reactions. However, it is only poorly understood which O2 uptake mechanism enzymes …

The re-emergence of tuberculosis in recent years led the World Health Organization (WHO)
to launch the Stop TB Strategy program. Beside repurposing the existing drugs and …

Carbohydrates are widely abundant molecules present in a variety of forms. For their
biosynthesis and modification, nature has evolved a plethora of carbohydrate-acting …

Enzymatic methods for the oxidation of alcohols are critically reviewed. Dehydrogenases
and oxidases are the most prominent biocatalysts, enabling the selective oxidation of …

The VAO flavoprotein family is a rapidly growing family of oxidoreductases that favor the
covalent binding of the FAD cofactor. In this review we report on the catalytic properties of …