Osmolytes are naturally occurring organic compounds, which represent different chemical
classes including amino acids, methylamines, and polyols. By accumulating high …

BACKGROUND Preimplantation embryos are particularly susceptible to in vitro
developmental blocks. These could be alleviated by lowering culture medium osmolarity …

Background Although cells require nutrients to proliferate, most nutrient exchange rates of
the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we …

The culture of murine oocytes and preimplantation embryos in vitro has been used
successfully for many years. However, this practice can result in cellular stress and reduced …

Mammalian preimplantation embryos follow a stereotypic pattern of development from
zygotes to blastocysts. Here, we use labeled nutrient isotopologue analysis of small …

In cattle, conceptus development after elongation relies on well-characterized, paracrine
interactions with the hosting maternal reproductive tract. However, it was unrecognized …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

The value of using the amino acid and fatty acid composition of follicular fluid as predictors
of embryo development was assessed in a bovine model of in-vitro maturation (IVM), IVF …

X-box binding protein-1 (XBP-1) is an important regulator of a subset of genes during
endoplasmic reticulum (ER) stress. In the current study, we analyzed endogenous XBP-1 …

The cryopreservation of red blood cells (RBCs) plays a key role in blood transfusion therapy.
Traditional cryoprotectants (CPAs) are mostly organic solvents and may cause side effects to …