Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Background: Podocyte biology is a developing science that promises to help improve
understanding of the mechanistic nature of multiple diseases associated with proteinuria …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …