[HTML][HTML] Macrophage polarization: different gene signatures in M1 (LPS+) vs. classically and M2 (LPS–) vs. alternatively activated macrophages
M Orecchioni, Y Ghosheh, AB Pramod… - Frontiers in …, 2019 - frontiersin.org
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …
macrophages are seeded in the early embryo before definitive hematopoiesis is …
[HTML][HTML] The glomerular filtration barrier: a structural target for novel kidney therapies
IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
Mechanisms of podocyte injury and implications for diabetic nephropathy
F Barutta, S Bellini, G Gruden - Clinical Science, 2022 - portlandpress.com
Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
A review of podocyte biology
P Garg - American journal of nephrology, 2018 - karger.com
Background: Podocyte biology is a developing science that promises to help improve
understanding of the mechanistic nature of multiple diseases associated with proteinuria …
understanding of the mechanistic nature of multiple diseases associated with proteinuria …
The integrin adhesome: from genes and proteins to human disease
SE Winograd-Katz, R Fässler, B Geiger… - … reviews Molecular cell …, 2014 - nature.com
The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …
transmembrane receptors have key roles in regulating multiple aspects of cellular …
Exploring the genetic basis of early-onset chronic kidney disease
A Vivante, F Hildebrandt - Nature Reviews Nephrology, 2016 - nature.com
The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …
adults. In the USA the most common diagnostic groups of renal disease that manifest before …
The cell biology of renal filtration
RP Scott, SE Quaggin - Journal of cell biology, 2015 - rupress.org
The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …
Ion channels and channelopathies in glomeruli
A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
[HTML][HTML] Regulation of the actin cytoskeleton in podocytes
J Blaine, J Dylewski - Cells, 2020 - mdpi.com
Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …
filtration of large proteins and macromolecules into the urine. Podocyte function is …
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …