Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

Alzheimer's disease is the most frequent cause of dementia worldwide, representing a
global health challenge, with a massive impact on the quality of life of Alzheimer's disease …

Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is
the leading cause of dementia worldwide. Increasingly, there have been reports of the …

Background It has been claimed that the retina can be used as a window to study brain
disorders. However, concerning Alzheimer's disease (AD), it still remains controversial …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. It compromises
patients' daily activities owing to progressive cognitive deterioration, which has elevated …

Abstract Sphingosine-1-phosphate receptor (S1PR) signaling regulates diverse
pathophysiological processes in the central nervous system. The role of S1PR signaling in …

Significance. Recent Alzheimer's disease (AD) patient studies have focused on retinal
analysis, as the retina is the only part of the central nervous system that can be imaged …

Background: Alzheimer's disease (AD) may present retinal changes before brain pathology,
suggesting the retina as an accessible biomarker of AD. The present work is a diachronic …

Abstract N-Methyl-D-aspartate (NMDA)-induced neuronal cell death is involved in a large
spectrum of diseases affecting the brain and the retina such as Alzheimer's disease and …

Recently a range of ocular manifestations such as retinal and lens amyloid-beta
accumulation and retinal nerve fiber layer loss have been proposed as potential biomarkers …