Cholesterol and its relatives possessing the 1, 2-cyclopentanoperhydrophenanthrene ring
system (Figure 1) form the sterolome, which comprises a chemical library of more than 1000 …

Fungal species are a very important source of many different enzymes, and the ability of
fungi to transform steroids has been used for several decades in the production of …

Paracoccidioides is a fungal pathogen and the cause of paracoccidioidomycosis, a health-
threatening human systemic mycosis endemic to Latin America. Infection by …

Background Fungal extracellular vesicles are able to cross the cell wall and transport
molecules that help in nutrient acquisition, cell defense, and modulation of the host defense …

Filamentous fungi are prolific repertoire of structurally diverse secondary metabolites of
remarkable biological activities such as lovastatin and paclitaxel that have been approved …

An efficient oxidative stress response is important to the fungal pathogen Paracoccidioides
to survive within the human host. In this study, oxidative stress was mimicked by exposure of …

Main conclusion This work reviews recent advances in the pathways and key enzymes of
steroidal saponins biosynthesis and sets the foundation for the biotechnological production …

Ergosterol is the predominant sterol of fungi and green algae. Although the biosynthetic
pathway for sterol synthesis in fungi is well established and is known to use C24-methylation …

Aim: To perform virtual screening of compounds based on natural products targeting
isocitrate lyase of Paracoccidioides brasiliensis. Materials & methods: Homology modeling …

Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from
the human host offer new chokepoint targets. Here, we present characterization and cell …