The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Developmental programming of non-communicable diseases is now an established
paradigm. With respect to hypertension and chronic kidney disease, adverse events …

The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

Several studies have shown that total nephron (glomerular) number varies widely in normal
human kidneys. Whereas the studies agree that average nephron number is approximately …

An adverse intrauterine environment is associated with an increased risk of elevated blood
pressure and kidney disease in later life. Many studies have focused on low birth weight …

Abstract Treatment and management of kidney disease currently presents an enormous
global burden, and the application of nanotechnology principles to renal disease therapy …

The kidney plays a fundamental role in maintaining body salt and fluid balance and blood
pressure homeostasis through the actions of its proximal and distal tubular segments of …

Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

MicroRNAs (miRNAs) are endogenous short (20–22 nucleotides) non-coding RNA
molecules that mediate gene expression. This is an important regulatory mechanism to …

Urinary extracellular vesicles (uEVs) are emerging as non‐invasive biomarkers for various
kidney diseases, but it is unknown how differences in nephron mass impact uEV excretion …