Infants born with severe central disorders of the hypothalamic‐pituitary‐gonadal axis
leading to gonadotropin deficiency not only lack pubertal development in adolescence, but …

In humans, the first 1000 days of life are pivotal for brain and organism development. Shortly
after birth, gonadotropin‐releasing hormone (GnRH) neurons in the hypothalamus are …

The aim of the study was to investigate whether the administration of gonadotropins to mimic
the physiological development of infants with congenital hypogonadotropic hypogonadism …

There are three waves of hypothalamic‐pituitary‐gonadal axis activation during life. The first
occurs from the 2nd trimester to the 3rd trimester of foetal life and the second, termed mini …

Precocious puberty refers to the emergence of secondary sexual traits before the typical age
for children of the same gender and race. It is classified into gonadotropin-dependent …