Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

The WAG/Rij rat model has recently gathered attention as a suitable animal model of
absence epileptogenesis. This latter term has a broad definition encompassing any possible …

Absence Epilepsy (AE) is a prototypic epileptic syndrome that develops during brain
maturation but cannot be fully explored in human patients. Genetic animal models …

The mammalian target of rapamycin (mTOR) pathway has been recently indicated as a
suitable drug target for the prevention of epileptogenesis. The mTOR pathway is known for …

Aim Epilepsy is one of the most common chronic brain disorders that affect millions of
people worldwide. In the present study, we investigated the effects of probiotic …

Different data suggest the involvement of specific inflammatory pathways in the
pathogenesis of epilepsy. Cyclooxygenase (COX), which catalyses the production of pro …

The WAG/Rij model is a well characterized and validated genetic animal epilepsy model in
which the for absence epilepsy highly characteristic spike-wave discharges (SWDs) develop …

The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as
models for generalized genetic epilepsy and in particular for childhood absence epilepsy …

Increased expression of interleukin-6 (IL-6) both in cerebrospinal fluid (CSF) and plasma is
closely associated with convulsive epilepsy and symptom severity of depression. By …

Summary Objective Statins (3‐hydroxy‐3‐methylglutaryl‐coenzyme A [HMG‐CoA]
reductase inhibitors) exert cholesterol‐independent pleiotropic effects that include …