Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of
cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD …

Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …

The broad-based legalization of cannabis use has created a strong need to understand its
impact on human health and behavior. The risks that may be associated with cannabis use …

Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a
wide range of therapeutically promising pharmacological effects either as a sole drug or in …

In recent years, the interest in cannabidiol (CBD) has increased because of the lack of
psychoactive properties. However, CBD has low solubility and bioavailability, variable …

Cannabidiol (CBD) is a major active component of the Cannabis plant, which, unlike
tetrahydrocannabinol (THC), is devoid of euphoria-inducing properties. During the last 10 …

GW Pharmaceuticals' formulation of highly purified cannabidiol oral solution is approved in
the United States for seizures associated with Lennox‐Gastaut and Dravet syndromes in …

Exogenous cannabinoids are structurally and pharmacologically diverse compounds that
are widely used. The purpose of this systematic review is to summarize the data …