Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer

CAK Borrebaeck - Nature Reviews Cancer, 2017 - nature.com
Interest in precision diagnostics has been fuelled by the concept that early detection of
cancer would benefit patients; that is, if detected early, more tumours should be resectable …

LC-MS-based metabolomics

B Zhou, JF Xiao, L Tuli, HW Ressom - Molecular BioSystems, 2012 - pubs.rsc.org
Metabolomics aims at identification and quantitation of small molecules involved in
metabolic reactions. LC-MS has enjoyed a growing popularity as the platform for …

Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies

PE Geyer, E Voytik, PV Treit, S Doll… - EMBO molecular …, 2019 - embopress.org
Plasma and serum are rich sources of information regarding an individual's health state, and
protein tests inform medical decision making. Despite major investments, few new …

Comparing the MicroRNA spectrum between serum and plasma

K Wang, Y Yuan, JH Cho, S McClarty, D Baxter… - 2012 - journals.plos.org
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate various biological
processes, primarily through interaction with messenger RNAs. The levels of specific …

Extracellular microRNA: a new source of biomarkers

A Etheridge, I Lee, L Hood, D Galas, K Wang - … Research/Fundamental and …, 2011 - Elsevier
MicroRNAs (miRNAs) are a recently discovered class of small, non-coding RNAs that
regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in …

Reversible versus Irreversible Binding of Transferrin to Polystyrene Nanoparticles: Soft and Hard Corona

S Milani, F Baldelli Bombelli, AS Pitek, KA Dawson… - ACS …, 2012 - ACS Publications
Protein adsorption to nanoparticles (NPs) is a key prerequisite to understand NP–cell
interactions. While the layer thickness of the protein corona has been well characterized in …

Interferences from blood collection tube components on clinical chemistry assays

RAR Bowen, AT Remaley - Biochemia medica, 2014 - hrcak.srce.hr
Sažetak Improper design or use of blood collection devices can adversely affect the
accuracy of laboratory test results. Vascular access devices, such as catheters and needles …

Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration …

MK Tuck, DW Chan, D Chia, AK Godwin… - Journal of proteome …, 2009 - ACS Publications
Specimen collection is an integral component of clinical research. Specimens from subjects
with various stages of cancers or other conditions, as well as those without disease, are …

Human body fluid proteome analysis

S Hu, JA Loo, DT Wong - Proteomics, 2006 - Wiley Online Library
The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

[HTML][HTML] Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

SE O'Bryant, V Gupta, K Henriksen, M Edwards… - Alzheimer's & …, 2015 - Elsevier
The lack of readily available biomarkers is a significant hindrance toward progressing to
effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based …