Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer
patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be …

The most common human cancers—lung, breast and prostate—have a great avidity for
bone, leading to painful and untreatable consequences. What makes some cancers, but not …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

The strength and integrity of our bones depends on maintaining a delicate balance between
bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result …

Patients with advanced prostate cancer often develop bone metastases, leading to bone
pain, skeletal fracture, and increased mortality. Bone provides a hospitable …

Breast cancer frequently metastasizes to the skeleton, and the associated bone destruction
is mediated by the osteoclast. Growth factors, including transforming growth factor-β (TGF-β) …

The skeleton is one of the most common sites for metastatic cancer, and tumors arising from
the breast or prostate possess an increased propensity to spread to this site. The growth of …

Breast cancer almost invariably metastasizes to bone in patients with advanced disease and
causes local osteolysis. Much of the morbidity of advanced breast cancer is a consequence …

In the present article, the steps involved in the process of tumor metastasis are discussed.
Several events are required for malignant cells to leave the primary tumor and proliferate at …

Breast cancer is the most common cancer among women. To date, 22 common breast
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …