Repurposing of chronically used drugs in cancer therapy: a chance to grasp

MA Hijazi, A Gessner, N El-Najjar - Cancers, 2023 - mdpi.com
Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

Drug repurposing for glioblastoma and current advances in drug delivery—a comprehensive review of the literature

S Alomari, I Zhang, A Hernandez, CY Kraft, D Raj… - Biomolecules, 2021 - mdpi.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with an
extremely poor prognosis. There is a dire need to develop effective therapeutics to …

In Vitro Drug Repurposing: Focus on Vasodilators

E Ribeiro, B Costa, F Vasques-Nóvoa, N Vale - Cells, 2023 - mdpi.com
Drug repurposing aims to identify new therapeutic uses for drugs that have already been
approved for other conditions. This approach can save time and resources compared to …

PATZ1-rearranged tumors of the central nervous system: characterization of a pediatric series of seven cases

S Rossi, S Barresi, GS Colafati, S Genovese… - Modern Pathology, 2024 - Elsevier
PATZ1-rearranged sarcomas are well-recognized tumors as part of the family of round cell
sarcoma with EWSR1-non-ETS fusions. Whether PATZ1-rearranged central nervous system …

Role of renin angiotensin system inhibitors and metformin in Glioblastoma Therapy: a review

S Dixon, AT O'connor, C Brooks-Noreiga… - Cancer Chemotherapy …, 2024 - Springer
Glioblastoma multiforme (GBM) is a highly aggressive and incurable disease accounting for
about 10,000 deaths in the USA each year. Despite the current treatment approach which …

Primary Intracranial Gliosarcoma: Is It Really a Variant of Glioblastoma? An Update of the Clinical, Radiological, and Biomolecular Characteristics

D La Torre, A Della Torre, E Lo Turco, P Longo… - Journal of Clinical …, 2023 - mdpi.com
Gliosarcomas (GS) are sporadic malignant tumors classified as a Glioblastoma (GBM)
variant with IDH-wild type phenotype. It appears as a well-circumscribed lesion with a …

Effect of electroacupuncture on global cerebral ischemia‑reperfusion injury in rats: A urine proteome analysis

X Zhang, Y Dai, F Ma, Y Ma, J Wang, X Li… - Brain and …, 2024 - Wiley Online Library
Background This study aimed to investigate dynamic urinary proteome changes of
electroacupuncture (EP) on cerebral ischemia‑reperfusion (CI/R) injured rats and to explore …

Inibidor da Enzima Conversora da Angiotensina como Potencial Alvo Terapêutico no Carcinoma Bucal

ESB Gomes - 2022 - repositorio.unimontes.br
O câncer tem demonstrado o seu grande impacto na saúde pública, diante disso a sua
relevância tem impactado no cenário mundial em razão de sua implicação de seus …