Research over the past years has provided increasing understanding about IL‐17‐
producing CD8+ T cells termed Tc17 or IL‐17+ CD8+ T cells, their distribution and role in a …

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a
critical regulator of adaptive immune responses. Cbl-b is essential for establishing the …

T cells are fundamental components in tumour immunity and cancer immunotherapies,
which have made immense strides and revolutionized cancer treatment paradigm. However …

In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …

Structural variations (SVs) are a major contributor of genetic diversity and phenotypic
variations, however their prevalence and functions in domestic animals are largely …

It is well established that extracellular proteins that negatively regulate T cell function, such
as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death …

Introduction The transcription factor HELIOS is primarily known for its expression in CD4
regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T …

Nontuberculous mycobacteria (NTM) are emerging opportunistic pathogens causing
pulmonary infection to fatal disseminated disease. NTM infections are steadily increasing in …

Background: The pathogenesis of multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE—an animal model of MS) is primarily mediated by T cells. However …

The term Tc17 cells refers to interleukin 17 (IL-17)-producing CD8+ T cells. While IL-17 is an
important mediator of mucosal defense, it is also centrally involved in driving the …