Severe burn injuries are the most traumatic and physically debilitating injuries affecting
nearly every organ system and leading to significant morbidity and mortality. Early burn …

Polymyxins are vital antibiotics for the treatment of multiresistant Gram-negative ESKAPE
pathogen infections. However, their clinical value is limited by their high nephrotoxicity and …

Research into advanced therapeutic materials is of growing importance worldwide,
particularly in the disease areas of infection, neurodegeneration, and oncology. Advances …

Background Amylase was the first enzyme to be characterized, and for the previous 200
years, its clinical role has been restricted to a diagnostic aid. Recent interface research has …

The development of nanotechnology-based antibiotic delivery systems (nanoantibiotics) is
an important challenge in the effort to combat microbial multidrug resistance. These systems …

The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting
toxicity, has highlighted the need for alternative approaches to combat infection. This study …

In order to render potent, but toxic antibiotics more selective, we have explored a novel
conjugation strategy that includes drug accumulation followed by infection‐triggered release …

Introduction Acute myeloid leukemia (AML) remains difficult to treat due to its heterogeneity
in molecular landscape, epigenetics and cell signaling alterations. Precision medicine is a …

Polymyxin B (PMB) is used as the last line therapy for multidrug-resistant Gram-negative
bacterial infections; however, nephrotoxicity is still a concern. Here, PMB carried with …

Since the 1970s, polysaccharides such as dextran, dextrin, hyaluronic acid, hydroxyethyl
starch, and polysialic acid have been investigated as carriers for therapeutic protein and …