Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …

Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Telomeres—repeated, noncoding nucleotide motifs and associated proteins that are found
at the ends of eukaryotic chromosomes—mediate genome stability and determine cellular …

Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …

Templated DNA repair that occurs during homologous recombination and replication stress
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …

The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA)
plays a crucial role in various DNA metabolic pathways, including DNA replication and …

Homologous recombination (HR) is essential for error-free repair of DNA double-strand
breaks, perturbed replication forks (RFs), and post-replicative single-stranded DNA (ssDNA) …

DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …

The dysregulation of apoptosis and DNA damage repair are two leading mechanisms of
cisplatin resistance. Two anticancer PtIV prodrugs with the formulas [Pt (NH3) 2Cl2 (L1) 2](1 …

ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous
recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament …