Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently
coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy …

The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and
hampers the widespread application of this powerful class of therapeutic agents. In that …

Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma
(PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in patients with type 2 …

Obesity is a condition that is characterized by the presence of excessive adipose tissue in
the body. Obesity has become one of the main health concerns worldwide since it can lead …

Liver injury could be caused by a variety of causes, including alcohol, drug poisoning,
autoimmune overreaction, etc. In the period of liver injury, hepatic stellate cells (HSCs) will …

Background and Objectives: A subject with diabetes and obesity is a class of the metabolic
disorder. The current investigation aimed to elucidate the potential biomarker and prognostic …

Simple Summary The innate immune system is a key player in the fight against tumors and
metastasis. Chemerin induces the migration of immune cells towards sites of inflammation …

Background Non-alcoholic steatohepatitis (NASH) is a spectrum of histological liver
pathologies ranging from hepatocyte fat accumulation, hepatocellular ballooning, lobular …

Adipocyte differentiation is a sequential process involving increased expression of
peroxisome proliferator-activated receptor gamma (PPARγ), adipocyte-specific gene …