Hypertensive disorders in pregnancy (HDP) represent some of the most important problems
faced by public health because HDP is a major cause of maternal and prenatal morbidity …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Although it has frequently been indicated that the causes of essential hypertension are not
known, this is only partially true because we have little information on genetic variations or …

Hypertension, or elevated arterial blood pressure, is a been operationally defined as the
blood pressure level substantial public health problem, affecting 25% of the above which …

Epidemiological, migration, intervention, and genetic studies in humans and animals
provide very strong evidence of a causal link between high salt intake and high blood …

Genome-wide association studies (GWAS) often identify disease-associated mutations in
intergenic and non-coding regions of the genome. Given the high percentage of the human …

Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene
became the first genetic element shown to impact substantially on human physical …

Progressive hepatic fibrosis and cirrhosis develops in 20% to 30% of patients with chronic
hepatitis C virus (HCV). We propose that host genetic factors influencing fibrogenesis may …

Background—The activated local atrial renin-angiotensin system (RAS) has been reported
to play an important role in the pathogenesis of atrial fibrillation (AF). We hypothesized that …

Blood pressure is critically controlled by angiotensins, which are vasopressor peptides
specifically released by the enzyme renin from the tail of angiotensinogen—a non-inhibitory …