Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Recent discoveries in zinc biology provide a new platform for discussing the primary
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …

Metallothioneins (MTs) are a class of ubiquitously occurring low molecular mass, cysteine-
and metal-rich proteins containing sulfur-based metal clusters formed with Zn (II), Cd (II), and …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Amyloid-β peptides (Aβ) are key molecules in Alzheimer's disease (AD) pathology as they
form amyloid plaques that are primary hallmarks of AD. There is increasing evidence …

Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

Protein misfolding and conformational changes are a cornerstone of neurodegenerative
diseases involving formation and deposition of toxic protein oligomers. Although mutations …

Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years
due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and …

In this perspective we list the many clinical, histopathological, genetic and chemical
observations relating copper to Alzheimer's disease (AD). We summarize how the …

Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in
metal homeostasis and detoxification. While known for their high affinity for d10 metal ions …