The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

INTRODUCTION Detection of pathogens by the innate immune system is an essential first
step in successful host defense against infection. Pathogens are typically detected by …

We need to apply novel findings towards sustainable approaches for treating and preventing
Shigella infections. Vaccines and alternative treatments are under development and may …

Shigella is a major cause of bacillary dysentery world-wide. It is divided into four species,
named S. flexneri, S. sonnei, S. dysenteriae, and S. boydii, which are distinct genomically …

Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-
negative pathogens with a unique virulence mechanism enabling them to inject bacterial …

Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless
enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research …

Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

The Shigella bacteria cause bacillary dysentery, which remains a significant threat to public
health. The genus status and species classification appear no longer valid, as compelling …

We have sequenced the genome of Shigella flexneri serotype 2a, the most prevalent
species and serotype that causes bacillary dysentery or shigellosis in man. The whole …