The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular
functions including protein folding and maturation and the maintenance of cellular …

The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is
complex in the sense that, under certain circumstances, autophagy constitutes a stress …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

▪ Abstract In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into
their native conformation and undergo posttranslational modifications important for their …

The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular
activities and survival. Conditions that interfere with ER function lead to the accumulation …

Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …

Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER)
induces a coordinated adaptive program called the unfolded protein response (UPR). The …

When protein folding in the endoplasmic reticulum (ER) is disrupted by alterations in
homeostasis in the ER lumen, eucaryotic cells activate a series of signal transduction …