[HTML][HTML] The current status of risk-stratified breast screening
Apart from high-risk scenarios such as the presence of highly penetrant genetic mutations,
breast screening typically comprises mammography or tomosynthesis strategies defined by …
breast screening typically comprises mammography or tomosynthesis strategies defined by …
[HTML][HTML] Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: a systematic review
Purpose This study aimed to systematically review current models for communicating
polygenic scores (PGS) and psycho-behavioral outcomes of receiving PGSs. Methods …
polygenic scores (PGS) and psycho-behavioral outcomes of receiving PGSs. Methods …
Why do people seek out polygenic risk scores for complex disorders, and how do they understand and react to results?
We sought to explore individuals' motivations for using their direct-to-consumer genetic
testing data to generate polygenic risk scores (PRSs) using a not-for-profit third-party tool …
testing data to generate polygenic risk scores (PRSs) using a not-for-profit third-party tool …
[HTML][HTML] Risk-stratified breast cancer screening incorporating a polygenic risk score: A survey of UK general practitioners' knowledge and attitudes
A Ayoub, J Lapointe, H Nabi, N Pashayan - Genes, 2023 - mdpi.com
A polygenic risk score (PRS) quantifies the aggregated effects of common genetic variants in
an individual. A 'personalised breast cancer risk assessment'combines PRS with other …
an individual. A 'personalised breast cancer risk assessment'combines PRS with other …
Human genetics society of Australasia position statement: use of polygenic scores in clinical practice and population health
Considerable progress continues to be made with regards to the value and use of disease
associated polygenic scores (PGS). PGS aim to capture a person's genetic liability to a …
associated polygenic scores (PGS). PGS aim to capture a person's genetic liability to a …
[HTML][HTML] Breast cancer polygenic risk scores: a 12-month prospective study of patient reported outcomes and risk management behavior
Purpose To prospectively assess patient reported outcomes and risk management behavior
of women choosing to receive (receivers) or decline (decliners) their breast cancer …
of women choosing to receive (receivers) or decline (decliners) their breast cancer …
Communicating polygenic risk scores in the familial breast cancer clinic
KD Gupta, G Gregory, B Meiser, R Kaur… - Patient education and …, 2021 - Elsevier
Objective To describe the communication of polygenic risk scores (PRS) in the familial
breast cancer setting. Methods Consultations between genetic healthcare providers (GHP) …
breast cancer setting. Methods Consultations between genetic healthcare providers (GHP) …
[HTML][HTML] Information needs on breast cancer genetic and non-genetic risk factors in relatives of women with a BRCA1/2 or PALB2 pathogenic variant
Objectives Comprehensive breast cancer (BC) risk models integrating effects of genetic
(GRF) and non-genetic risk factors (NGRF) may refine BC prevention recommendations. We …
(GRF) and non-genetic risk factors (NGRF) may refine BC prevention recommendations. We …
A qualitative study exploring the consumer experience of receiving self-initiated polygenic risk scores from a third-party website
K Lowes, K Borle, L Folkersen, J Austin - European Journal of Human …, 2023 - nature.com
The number of people accessing their own polygenic risk scores (PRSs) online is rapidly
increasing, yet little is known about why people are doing this, how they react to the …
increasing, yet little is known about why people are doing this, how they react to the …
Informed choice and attitudes regarding a genomic test to predict risk of colorectal cancer in general practice
S Saya, JG McIntosh, IM Winship, S Milton… - Patient Education and …, 2022 - Elsevier
Objective A genomic test to predict personal risk of colorectal cancer (CRC) that targets
screening and could be feasibly implemented in primary care. We explored informed …
screening and could be feasibly implemented in primary care. We explored informed …