The grid code for ordered experience

JW Rueckemann, M Sosa, LM Giocomo… - Nature Reviews …, 2021 - nature.com
Entorhinal cortical grid cells fire in a periodic pattern that tiles space, which is suggestive of a
spatial coordinate system. However, irregularities in the grid pattern as well as responses of …

Neural ensembles in navigation: From single cells to population codes

EAA Jones, LM Giocomo - Current opinion in neurobiology, 2023 - Elsevier
The brain can represent behaviorally relevant information through the firing of individual
neurons as well as the coordinated firing of ensembles of neurons. Neurons in the …

Neuronal representation of environmental boundaries in egocentric coordinates

JR Hinman, GW Chapman, ME Hasselmo - Nature communications, 2019 - nature.com
Movement through space is a fundamental behavior for all animals. Cognitive maps of
environments are encoded in the hippocampal formation in an allocentric reference frame …

Neurophysiological coding of space and time in the hippocampus, entorhinal cortex, and retrosplenial cortex

AS Alexander, JC Robinson… - Brain and …, 2020 - journals.sagepub.com
Neurophysiological recordings in behaving rodents demonstrate neuronal response
properties that may code space and time for episodic memory and goal-directed behaviour …

Grid cell disruption in a mouse model of early Alzheimer's disease reflects reduced integration of self-motion cues

J Ying, A Reboreda, M Yoshida, MP Brandon - Current Biology, 2023 - cell.com
Converging evidence from human and rodent studies suggests that disrupted grid cell
coding in the medial entorhinal cortex (MEC) underlies path integration behavioral deficits …

Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells

ME Lepperød, AC Christensen, KK Lensjø… - Science …, 2021 - science.org
Grid cells in the medial entorhinal cortex (MEC) exhibit remarkable spatial activity patterns
with spikes coordinated by theta oscillations driven by the medial septal area (MSA). Spikes …

Advantages and detection of phase coding in the absence of rhythmicity

D Bush, N Burgess - Hippocampus, 2020 - Wiley Online Library
The encoding of information in spike phase relative to local field potential (LFP) oscillations
offers several theoretical advantages over equivalent firing rate codes. One notable example …

Entorhinal velocity signals reflect environmental geometry

RGK Munn, CS Mallory, K Hardcastle… - Nature …, 2020 - nature.com
The entorhinal cortex contains neurons that represent self-location, including grid cells that
fire in periodic locations and velocity signals that encode running speed and head direction …

Path integration maintains spatial periodicity of grid cell firing in a 1D circular track

PY Jacob, F Capitano, B Poucet, E Save… - Nature …, 2019 - nature.com
Entorhinal grid cells are thought to provide a 2D spatial metric of the environment. In this
study we demonstrate that in a familiar 1D circular track (ie, a continuous space) grid cells …

Ripple band phase precession of place cell firing during replay

D Bush, HF Olafsdottir, C Barry, N Burgess - Current Biology, 2022 - cell.com
Neuronal" replay," in which place cell firing during rest recapitulates recently experienced
trajectories, is thought to mediate the transmission of information from hippocampus to …