Covering 1970–2001This review covers the functionally diverse type III polyketide synthase
(PKS) superfamily of plant and bacterial biosynthetic enzymes, from the discovery of …

Polyphenols have become an intense focus of research interest because of their perceived
health-beneficial effects, such as anti-carcinogenic, anti-atherogenic, anti-inflammatory, anti …

Background: Deconvoluting protein kinase signaling pathways using conventional genetic
and biochemical approaches has been difficult because of the overwhelming number of …

4-Anilinoquinazolines represent an important class of protein kinase inhibitor. Modes of
binding for two members of this inhibitor class were determined by X-ray crystallographic …

Protein tyrosine kinases (PTKs) play a key role in normal cell and tissue development.
Enhanced PTK activity is intimately correlated with proliferative diseases, such as cancers …

In the past decade it has become apparent that many diseases result from aberrations in
signaling pathways. These include proliferative diseases such as cancers, atherosclerosis …

Intuitive, visual rendering—mapping—of high-dimensional chemical spaces (CS), is an
important topic in chemoinformatics. Such maps were so far dedicated to specific compound …

Activation of transcription factor NF-κB is regulated by phosphorylation and subsequent
degradation of its inhibitory subunit IκB. The signal-induced phosphorylation of IκB involves …

Protein kinases are critical components of signaling pathways and trigger various biological
events. Several members of this superfamily are interesting targets for novel therapeutic …

The N-methylanilino group in 2-(N-methylanilino)-3-formylchromones, obtained in high yield
by rearrangement of C (4-oxo-4H [1]-benzopyran-3-yl)-N-phenylnitrones to 2-anilino-3 …