Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Blood− brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

R Prakash, ST Carmichael - Current opinion in neurology, 2015 - journals.lww.com
Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

[HTML][HTML] Brain–immune interactions and neuroinflammation after traumatic brain injury

V Dinet, KG Petry, J Badaut - Frontiers in neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) is the principal cause of death and disability in children and
young adults. Clinical and preclinical research efforts have been carried out to understand …

Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood–brain barrier disruption …

OY Glushakova, D Johnson, RL Hayes - Journal of neurotrauma, 2014 - liebertpub.com
Traumatic brain injury (TBI) is a significant risk factor for chronic traumatic encephalopathy
(CTE), Alzheimer's disease (AD), and Parkinson's disease (PD). Cerebral microbleeds, focal …

Chronic cerebrovascular dysfunction after traumatic brain injury

A Jullienne, A Obenaus, A Ichkova… - Journal of …, 2016 - Wiley Online Library
Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long‐term
alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form …

[HTML][HTML] Epilepsy related to traumatic brain injury

A Pitkänen, R Immonen - Neurotherapeutics, 2014 - Elsevier
Post-traumatic epilepsy accounts for 10–20% of symptomatic epilepsy in the general
population and 5% of all epilepsy. During the last decade, an increasing number of …

[HTML][HTML] Disruptions in resting state functional connectivity and cerebral blood flow in mild traumatic brain injury patients

C Sours, J Zhuo, S Roys, K Shanmuganathan… - PLoS …, 2015 - journals.plos.org
Mild traumatic brain injury (mTBI) is often occult to conventional imaging techniques.
However, there is growing evidence that mTBI patients who lack evidence of structural …

[HTML][HTML] Etiology matters–genomic DNA methylation patterns in three rat models of acquired epilepsy

KJ Dębski, A Pitkanen, N Puhakka, AM Bot, I Khurana… - Scientific reports, 2016 - nature.com
This study tested the hypothesis that acquired epileptogenesis is accompanied by DNA
methylation changes independent of etiology. We investigated DNA methylation and gene …

Chronic histopathological and behavioral outcomes of experimental traumatic brain injury in adult male animals

ND Osier, SW Carlson, A DeSana… - Journal of …, 2015 - liebertpub.com
The purpose of this review is to survey the use of experimental animal models for studying
the chronic histopathological and behavioral consequences of traumatic brain injury (TBI) …

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

RD Brady, PM Casillas-Espinosa, DV Agoston… - Neurobiology of …, 2019 - Elsevier
Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences
of traumatic brain injury (TBI). It is challenging to study the effects, underlying …